Synapses are fundamental structures linking nerve cells and it is essential to characterize human synapse proteins to understand the extent and significance of synapses to human disease, behavior and to find new diagnostic and therapeutic approaches. The postsynaptic density (PSD) comprises an extremely organized structure and signaling complex proteins that assist and critical for receptor, signaling, neurotransmission and synaptic plasticity. Hence, as a result of various inefficiencies effects, synaptic dysfunction in neuronal communication leads to cause of various psychiatric and neurologic diseases namely Alzheimer’s disease (AD), Parkinson’s disease, mental retardation and schizophrenia. Hence, understanding synapse establishes important targets for treatments, to slow progression, preserve cognitive and functional abilities in the various synaptic diseases.
Therefore, our Insilco objectives and methods mainly involve the identification, annotation and thorough understanding of proteome of PSD proteins, through their sequence, structure, modelling and effect of Mutations on these proteins on diseases. Likewise, Molecular protein interaction network/pathway analysis, protein function conservation/ evolution were evaluated to understand disease mechanisms. Our results reveal that, 1461 proteins retrieved were analyzed for sequence, structure and functions and further considered for their involvement in disease. Out of 1461, approximately 409 proteins were found to be involved in various Nervous System diseases. Further outcomes exhibited disease-specific protein differences. Mutation examination showed the prominent kind of diseases. Network-Hub analysis conclusions reveal new drug target associations between these diseases and high degree of molecular complexity. Thus our Insilco results suggest new therapeutic strategies for disease diagnosis and drug development.