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Brain Injury Knowledge Ontology for Traumatic Brain Injury (BIKO-TBI)
Monique C. Surles-Zeigler, Jeffrey S. Grethe, Adam R. Ferguson, Maryann E. Martone
Presenting author:
Monique C. Surles-Zeigler
Traumatic brain injury (TBI) is defined as an insult to the brain from an external force and is a significant cause of morbidity and mortality in the United States. However, no effective therapeutics currently exist for this injury. Although several therapies and procedures have been deemed successful for TBI treatment in preclinical research studies, they have not translated to human patients. These discouraging results have left many scientists perplexed, questioning the needed role of animal models for drug discovery in TBI. One major hurdle to improving the efficacy of translational TBI treatment, while often overlooked, is the methodological variance that exists between and among published research studies in the same species and to translate that knowledge across multiple species. The initial steps to address these knowledge gaps are identifying these studies and understanding the language used by diverse researchers to describe and report their research by creating an ontology, but there is currently no ontology to organize and aid TBI translational research. The Brain Injury Knowledge Ontology for TBI (BIKO-TBI) is being developed to create a standardized ontology to define and connect experimental design parameters (methods) and outcome measures used in preclinical and clinical TBI therapy studies. BIKO-TBI will be in compliance with Open Biological and Biomedical Ontology (OBO) and Protege community best practices. It will use multiple knowledge sources to increase reuse of and interoperability, including pre-existing terms within community ontologies, preclinical Common Data Elements (CDE), and clinical CDE, augmented with new terms extracted from the literature as necessary. BIKO will provide a machine-readable way to represent the methodologies used in TBI therapeutic studies. The first version of BIKO-TBI will focus on major preclinical TBI models, clinical pathophysiology, and three therapies that have translated to human studies- hypothermia, progesterone, and citicoline.