Browser-Based Neuron Simulation and Analysis Laboratory
Presenting author:
A browser-based neuron simulator and analysis application is presented that allows users to intuitively visualize and interpret numerical results across multiple simulations. Currently in use by educators and researchers, the application is part of an instructional website devoted to the topic of applied neural control. The application enables students and researchers to perform simulations using standard web browsers instead of requiring specialized software installation. For simulations, the user selects a physics-based model for a single neuron. Currently, the library contains two models: (1) The canonical Hodgkin-Huxley neuron; and (2) a published model of a human node of Ranvier. The user may specify any number of time-delayed pulse stimuli which can be saved and reused for future experiments. Additionally, the user has the option to see and modify all of the 40 model parameters. For analysis, graphs of the simulation results allow the user to move their mouse pointer across the time axis and instantly see quantitative values for the amplitudes of model properties (e.g. membrane voltage and currents). An integrated, multifunctional analysis tool allows the user to automatically capture selected simulation results for comparison to other simulations. The selected data can be instantly graphed in the browser, and they can also be exported to a data file in comma-separated-value format. In summary, the application fosters universal access to a virtual laboratory that includes neuron simulation and data analysis through a standard interface. It also provides intuitive features for the design and analysis of complex experiments with customized model configurations.